@article{MAIGODA_REFDANITA_IDRAMSYAH_2022, title={THE EFFECTIVENESS OF GUAVA (Psidium guajava) AND SENDUDUK LEAVES (Melastoma malabathricum L.) EXTRACT GEL TOWARDS THE INFLAMMATION MARKERS AND COLLAGENS ON INDUCED MALE RATS (SPRAGUE DAWLEY) WITH DIABETES}, volume={51}, url={https://jms.mabjournal.com/index.php/mab/article/view/2152}, DOI={10.55230/mabjournal.v51i1.2152}, abstractNote={<p>This study aimed to measure the effectiveness of a mixed extract gel from <em>Melastoma malabathricum</em> L. (ML) and <em>Psidium guajava</em> leaves (PG) on inflammatory markers and collagen distribution wound tissue in rats (Sprague Dawley) induced with diabetes. This was an experimental study with a randomized block design to 20 male rats divided into 4 treatment groups. Group 1 is negative control (gel blank), Group 2 is positive control (clindamycin gel), Group 3 used 4% gel formula mixture of ML + PG leaves, and Group 4 used 6% gel formula, a mixture of ML + PG leaves extract the gel. The results showed that there was a significant difference (<em>p</em><0.001) in total Tumor Necrosis Factor-alpha (TNF-α) treated with 6% extract gel (ML + PG) from a level of 25.0 pg/mL on the 2<sup>nd</sup> day to 1.68 pg/mL on the 6<sup>th</sup> day. The smallest wound diameter was 0.75 mm<sup>2</sup> as observed on the 6<sup>th </sup>day in rats treated with 6% extract gel (ML + PG). The largest distribution of collagen area was 219,8 (86,2%) treated by 6% extract gel (ML + PG).</p>}, number={1}, journal={Malaysian Applied Biology}, author={MAIGODA, TONNY CORTIS and REFDANITA and IDRAMSYAH}, year={2022}, month={Mar.}, pages={157–162} }