TY - JOUR AU - ABD MAJID, NOOR AL MAJIDAH AU - ISHAK, MUHAMMAD IQBAL AU - MURUGAPIRAN, JAGATHIS WEE VANNIAR AU - ABDUL AZIZ, NOR AZLINA AU - BASRIPUZI NURUL HAYYAN, PY - 2022/09/30 Y2 - 2024/03/29 TI - MULTIPLE ANTHELMINTIC RESISTANCE AMONG DORPER SHEEP DETECTED WITH PHENOTYPIC MARKERS AGAINST PARASITIC GASTROENTERITIS JF - Malaysian Applied Biology JA - MAB VL - 51 IS - 3 SE - Research Articles DO - 10.55230/mabjournal.v51i3.2260 UR - https://jms.mabjournal.com/index.php/mab/article/view/2260 SP - 107-115 AB - <p class="p1">Parasitic gastroenteritis (PGE) is a significant disease that affects small ruminant production. PGE is controlled exclusively by chemical anthelmintics but restricted by anthelmintic resistance. Hence, dependence on anthelmintics needs to be reduced. This study aimed to investigate the anthelmintic resistance status of a Dorper sheep farm while determining the phenotypic markers of resistance to PGE. Sheep that met the criteria of the Faecal Egg Count Reduction Test (FECRT) were divided into a control and four treatment groups of 11 to 13 animals per group. Faecal and blood samples at pre- and post-treatments were subjected to faecal egg counts (FEC), faecal culture, packed cell volume (PCV) and peripheral eosinophil counts (PEC). The data were analysed by Spearman rank correlation and two-way ANOVA. FECRT showed resistance towards albendazole, levamisole, fenbendazole and ivermectin which was predominated by <em>Haemonchus contortus</em>. Significant negative correlations were observed between FEC and PCV in control (<em>r</em>=-0.88, <em>p</em>&lt;0.01), fenbendazole (<em>r</em>=-0.58, <em>p</em>&lt;0.01) and ivermectin (<em>r</em>=-0.69, <em>p</em>&lt;0.01) groups. Significant positive correlations were detected between FEC and PEC in control (<em>r</em>=0.95, <em>p</em>&lt;0.01) and levamisole (<em>r</em>=0.56, <em>p</em>&lt;0.01) groups. This study shows multiple anthelmintic resistance with promising resistant characteristics against PGE among sheep.</p> ER -