Change in Immune Biomarkers of Laboratory Mice Responding to Experimental Inoculation of Different Drinking Water Quality from Selected Dairy Farms

https://doi.org/10.55230/mabjournal.v52i3.2676

Authors

  • Faez Firdaus Abdullah Jesse Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • Nagachandra Rao Gopi Naidu Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • Bura Thlama Paul Department of Animal Science and Fisheries, Faculty of Agriculture and Forestry Science, Universiti Putra Malaysia Campus Bintulu Sarawak, Malaysia; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Maiduguri, 600230, Borno State, Nigeria
  • Eric Lim Teik Chung Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Faculty of Environmental Studies, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia https://orcid.org/0000-0003-1038-1057
  • Wan Lutfi Wan Johari Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069 Bama Road, Maiduguri, Nigeria
  • Yusuf Abba Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • Mohd Azmi Mohd Lila Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • Mohd Jefri Norsidin Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

Keywords:

Biomarkers, dairy cattle farm, drinking water, host cell responses, mice, water quality

Abstract

Current knowledge of abnormal physiological responses in livestock due to consumption of substandard water is  limited. This study was designed to explore the host cell responses in mice orally inoculated with different drinking water qualities from selected dairy cattle farms. A total of 28 female mice used in this study were divided into Group 1- negative control (treated with sterile deionized distilled water), Group 2 - treated with good quality water sample, Group 3 - treated with moderate quality water sample, and Group 4 - treated with unsatisfactory quality water sample. All the mice were given 0.25 mL of water samples three times daily for 30 days. Blood samples were collected from all mice before euthanasia at 30 days post-inoculation for reproductive hormones and biomarkers analyses. All treatment groups showed significant (p<0.05) weight loss compared to the control group. There was a significant difference in the serum immunoglobulin-G (IgG), immunoglobulin-M (IgM), interleukin-12 (IL-12), haptoglobin (Hp), and serum amyloid A (SAA) profiles of mice among the different water quality treatments as compared to the control group (p<0.05). In conclusion, the host cell responses exhibited by the mice in the treatment groups indicates a high risk of potential negative effect on the production and health of the livestock due to long-term consumption of drinking water with subpar quality.

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Published

30-09-2023

How to Cite

Jesse, F. F. A., Naidu, N. R. G. ., Paul, B. T. ., Chung, E. L. T. ., Johari, W. L. W. ., Abba, Y. ., Lila, M. A. M. ., & Norsidin, M. J. . (2023). Change in Immune Biomarkers of Laboratory Mice Responding to Experimental Inoculation of Different Drinking Water Quality from Selected Dairy Farms. Malaysian Applied Biology, 52(3), 23–28. https://doi.org/10.55230/mabjournal.v52i3.2676

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