MULTIPLE ANTHELMINTIC RESISTANCE AMONG DORPER SHEEP DETECTED WITH PHENOTYPIC MARKERS AGAINST PARASITIC GASTROENTERITIS

NOOR AL MAJIDAH  ABD MAJID; MUHAMMAD IQBAL  ISHAK; JAGATHIS WEE VANNIAR  MURUGAPIRAN; NOR AZLINA  ABDUL AZIZ; BASRIPUZI NURUL HAYYAN

doi:10.55230/mabjournal.v51i3.2260

Authors

NOOR AL MAJIDAH ABD MAJID Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Jalan Padang Tembak, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia; Lembaga Kemajuan Tanah Persekutuan, Menara FELDA, Platinum Park, No. 11, Persiaran KLCC, 50088, Kuala Lumpur, Malaysia
MUHAMMAD IQBAL ISHAK Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Jalan Padang Tembak, Pengakalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia; Projek Integrasi Ternakan Felda Chuping, 02500 Kangar, Perlis, Malaysia
JAGATHIS WEE VANNIAR MURUGAPIRAN Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Jalan Padang Tembak, Pengakalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia
NOR AZLINA ABDUL AZIZ Department of Veterinary Pathology & Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Malaysia
BASRIPUZI NURUL HAYYAN
basripuzi@umk.edu.my
Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Jalan Padang Tembak, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia

Keywords:

anthelmintic resistance, parasitic gastroenteritis, phenotypic marker, faecal egg count, packed cell volume, peripheral eosinophil count

Abstract

Parasitic gastroenteritis (PGE) is a significant disease that affects small ruminant production. PGE is controlled exclusively by chemical anthelmintics but restricted by anthelmintic resistance. Hence, dependence on anthelmintics needs to be reduced. This study aimed to investigate the anthelmintic resistance status of a Dorper sheep farm while determining the phenotypic markers of resistance to PGE. Sheep that met the criteria of the Faecal Egg Count Reduction Test (FECRT) were divided into a control and four treatment groups of 11 to 13 animals per group. Faecal and blood samples at pre- and post-treatments were subjected to faecal egg counts (FEC), faecal culture, packed cell volume (PCV) and peripheral eosinophil counts (PEC). The data were analysed by Spearman rank correlation and two-way ANOVA. FECRT showed resistance towards albendazole, levamisole, fenbendazole and ivermectin which was predominated by Haemonchus contortus. Significant negative correlations were observed between FEC and PCV in control (r=-0.88, p<0.01), fenbendazole (r=-0.58, p<0.01) and ivermectin (r=-0.69, p<0.01) groups. Significant positive correlations were detected between FEC and PEC in control (r=0.95, p<0.01) and levamisole (r=0.56, p<0.01) groups. This study shows multiple anthelmintic resistance with promising resistant characteristics against PGE among sheep.

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