EFFECTS OF PURE AND FAKE HONEY ON GLUCOSE AND LIPID PROFILE in vitro AND in vivo STUDY

MUHAMMAD FAIZ  ZULKIFLI; SUHANA  SAMAT; NURUL SHAHIRAH  MOHD AZAM; FRANCIS KANYAN  ENCHANG; ABDULLAH ABD  RAZAK; FUZINA NOR  HUSSEIN; WAN IRYANI WAN  ISMAIL

doi:10.55230/mabjournal.v49i4.1620

Authors

MUHAMMAD FAIZ ZULKIFLI Cell Signaling and Biotechnology (CeSBTech), Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia
SUHANA SAMAT Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia
NURUL SHAHIRAH MOHD AZAM Cell Signaling and Biotechnology (CeSBTech), Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia
FRANCIS KANYAN ENCHANG Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia
ABDULLAH ABD RAZAK Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia
FUZINA NOR HUSSEIN Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
WAN IRYANI WAN ISMAIL
waniryani@umt.edu.my
Cell Signaling and Biotechnology (CeSBTech), Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia

Keywords:

Fake honey, health complications, natural honey, pure honey, obesity

Abstract

Honey authenticity is one of the most critical honey trading issues worldwide. Fake honey (FH) represents almost 80% of the honey market in Malaysia. Apart from violating consumer’s rights, FH consists of none of the beneficial nutritional value other than pure honey (PH). Moreover, prolonged consumption of FH may cause harm to human health. However, data regarding these issues is limited. In this study, both PH and FH were tested using 3T3-L1 adipocytes and in high-fat diet (HFD)-induced obese Sprague Dawley rats. Initially, a physicochemical analysis was performed on both the honey samples according to the Codex Alimentarius Commission and International Honey Commission procedures. After 72 hr, PH significantly reduced lipid accumulation and triglyceride levels in the adipocytes. In the rats, low glucose, cholesterol, and triglyceride levels were significantly detected after orally administered for 16 weeks. Conversely, FH significantly induced higher lipid accumulation and triglyceride levels in adipocytes and excess high blood glucose, cholesterol, and triglyceride levels in rats. The results demonstrated that FH has negative effects on lipid metabolism, and prolonged consumption may cause health complications. Furthermore, prompt actions are required to address this problem.