INTERFERENCES OF HbA1c ANALYSIS IN HOSPITAL UNIVERSITI SAINS MALAYSIA – 3 YEARS STUDY

https://doi.org/10.55230/mabjournal.v50i2.1978

Authors

  • NOORAZLIYANA SHAFII Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia https://orcid.org/0000-0002-3959-4534
  • NOOR AZLIN AZRAINI CHE SOH Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • TUAN SALWANI TUAN ISMAIL Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • JULIA OMAR Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • WAN NORLINA WAN AZMAN Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia https://orcid.org/0000-0001-7483-1585
  • ANIZA MAT JELANI Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • WAN NOR FAZILA HAFIZAN WAN NIK Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • IBRAHIM ISMAIL Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • NUR KARYATEE KASSIM School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • HANIM AFZAN IBRAHIM School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • NAJIB MAJDI YAACOB Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia https://orcid.org/0000-0002-6860-1430

Keywords:

carbamylated haemoglobin, haemoglobin variants, HbA1c, HPLC, interferences, labile A1c

Abstract

Haemoglobin A1c (HbA1c) is used to monitor glycaemic control and predict diabetic complications. Measurement of HbA1c can be interfered by haemoglobin (Hb) variant and other Hb derivatives include carbamylated Hb and elevated labile A1c. This study is to determine the percentages and type of interferences during HbA1c analysis and the percentages of non- reportable HbA1c results. This is a cross-sectional study using retrospective data of HbA1c. The HbA1c is measured on Biorad D10 using the ion-exchange high-performance liquid chromatography method. The data were analyzed using descriptive statistics. A total of 26,560 patients were included. The result showed the presence of interferences of 2269 (8.56%). The most common causes of the interferences were the Hb variant (8.48%) followed by carbamylated Hb and labile A1c (0.03% each). The non-reportable HbA1c results were 0.46% with the Hb variant contributed most of the causes. By knowing the presence of interferences particularly the Hb variant, the HbA1c results hopefully are interpreted with caution and correct management can be given to the patients.

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Published

30-11-2021

How to Cite

SHAFII, N., CHE SOH, N. A. A. ., TUAN ISMAIL, T. S., OMAR, J., WAN AZMAN, W. N., MAT JELANI, A., WAN NIK, W. N. F. H., ISMAIL, I., KASSIM, N. K., IBRAHIM, H. A. ., & YAACOB, N. M. (2021). INTERFERENCES OF HbA1c ANALYSIS IN HOSPITAL UNIVERSITI SAINS MALAYSIA – 3 YEARS STUDY. Malaysian Applied Biology, 50(2), 19–23. https://doi.org/10.55230/mabjournal.v50i2.1978

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