ALPHA-MANGOSTIN (Garcinia mangostana Linn.) AND ITS POTENTIAL APPLICATION IN MITIGATING CHRONIC WOUND HEALING
Keywords:
Chronic wounds, Garcinia mangostana, natural product, wound healingAbstract
Wound healing is a complex and dynamic cellular process to restore tissue function. Current treatments for chronic wounds especially diabetic ulcers are expensive, with adverse effects. Recently, numerous researchers have focused on the potential effect of natural products on wound healing. One of them is mangosteen (Garcinia mangostana Linn). It is a well-known tropical fruit that is native to Southeast Asia. The active ingredient of mangosteen pericarp contains xanthones that exhibit a wide range of pharmacological activities, including anti-inflammatory and anti-bacterial properties which are the core elements needed in wound healing. Firstly, this review discusses the concepts of abnormal and normal wound healing mechanisms. Then an in depth observation of the pharmacological activities of mangosteen and its derivatives was presented to study their potentially beneficial applications in the treatment of chronic wound healing which is a contemporary medical issue.
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Abrigo, M., McArthur, S.L. & Kingshott, P.J. 2014. Electrospun nanofibers as dressings for chronic wound care: Advances, challenges and future prospects. Journal of Macromolecular Bioscience, 14(6): 772-792. DOI: https://doi.org/10.1002/mabi.201300561
Agyare, C., Osafo, N. & Boakye, Y.D. 2018. Biomarkers of wound healing: Wound Healing Current Perspectives. IntechOpen. 24-30 pp. DOI: https://doi.org/10.5772/intechopen.80222
Aukkanimart, R., Boonmars, T., Sriraj, P., Sripan, P., Songsri, J., Ratanasuwan, P., Laummaunwai, P., Boueroy, P., Khueangchaingkhwang, S. & Pumhirunroj, B. 2017. In vitro and in vivo inhibitory effects of α-mangostin on cholangiocarcinoma cells and allografts. Asian Pacific Journal of Cancer Prevention, 18(3): 707.
Berghe, W.V. & Haegeman,G. 2010. Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: Myth or reality?. Current Drug Metabolism, 11(5): 436-450. DOI: https://doi.org/10.2174/138920010791526079
Boonmak, N., Niyompanich, J., Chuysinuan, P., Niamlang, P. & Ekabutr, P. 2018. Preparation of mangosteen extract-loaded poly (vinyl acetate) for use as an antibacterial spray-on dressing. Journal of Drug Delivery Science and Technology, 46: 322- 329. DOI: https://doi.org/10.1016/j.jddst.2018.05.033
Caley, M.P., Martins, V.L. & Toole, E.A. 2015. Metalloproteinases and wound healing. Advances in Wound Care, 4(4): 225-234. DOI: https://doi.org/10.1089/wound.2014.0581
Chinnappan, S., Ranganathan, V., Panneerselvan, J., Karikalan, B., Vasanthan, T. & Shienrun, W. 2020. Evaluation of wound healing activity of alpha mangostin ointment in rats. International Journal of Research in Pharmaceutical Sciences, 11: 1090-1087. DOI: https://doi.org/10.26452/ijrps.v11iSPL4.4247
Darby, I.A. & Hewitson, T. 2007. Fibroblast differentiation in wound healing and fibrosis. International Review of Cytology, 257: 143-179. DOI: https://doi.org/10.1016/S0074-7696(07)57004-X
Demidova-Rice, T.N., Hamblin, M.R. & Herman I.M. 2012. Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: Normal and chronic wounds: biology, causes, and approaches to care. Advance Skin Wound Care, 25(7): 304. DOI: https://doi.org/10.1097/01.ASW.0000416006.55218.d0
Dulmovits, B.M. & Herman, I.M. 2012. Microvascular remodeling and wound healing: A role for pericytes. Institute Journal Biochem Cell Biology, 44(11): 1800-1812. DOI: https://doi.org/10.1016/j.biocel.2012.06.031
Febrina, D., Milanda, T. & Muchtaridi, M. 2018. Pharmacological activity Garcinia mangostana linn : A review. International Journal of Current Medical Sciences, 8(5):430-433.
Gondokesumo, M. E., Wismandanu, O., Hartady, T., Rosdianto, A. M., Goenawan, H., Lesmana, R., Wathoni, N. & Supratman, U. 2019. Garcinia mangostana extract enhances skin epithelialization in rat induced burn injury. Pakistan Veterinary Journal, 39(3): 365-370. DOI: https://doi.org/10.29261/pakvetj/2019.059
Gondokesumo, M.E., Sumitro, S.B., Handono, K., Pardjianto, B. & Widowati,W. 2020. A computational study to predict wound healing agents from the peel of the mangosteen (Garcinia mangostana Linn) extract. Institute Journal Bio Automation, 24(3): 265-276.
Gottrup, F. 2004. A specialized wound-healing center concept: Importance of a multidisciplinary department structure and surgical treatment facilities in the treatment of chronic wounds The American Journal of Surgery, 187(5): 38-43. DOI: https://doi.org/10.1016/S0002-9610(03)00303-9
Hafeez, B. B., Mustafa, A., Fischer, J. W., Singh, A., Zhong, W., Shekhani, M.O., Meske, L., Havighurst, T., Kim, K. & Verma, A. 2014. α Mangostin: A dietary antioxidant derived from the pericarp of Garcinia mangostana L. inhibits pancreatic tumor growth in xenograft mouse model. Antioxidants and Redox Signaling, 21(5): 682-699. DOI: https://doi.org/10.1089/ars.2013.5212
Han, G. & Ceilley, R. 2017. Chronic wound healing: A review of current management and treatments. Advances in Therapy, 34(3): 599 -610. DOI: https://doi.org/10.1007/s12325-017-0478-y
Hanafiah, O. A., Abidin, T., Ilyas, S., Nainggolan, M. & Syamsudin, E. 2019. Wound healing activity of binahong (Anredera cordifolia (Ten.) Steenis) leaves extract towards NIH-3T3 fibroblast cells. Journal of International Dental and Medical Research, 12(3): 854-858.
Hsu, S. 2005. Green tea and the skin. Journal of The American Academy of Dermatology, 52(6): 1049- 1059. DOI: https://doi.org/10.1016/j.jaad.2004.12.044
Ibrahim, M.Y., Hashim, N.M., Mariod, A.A., Moha, S., Abdulla, M.A., Abdelwahab, S.I. & Arbab, I.A. 2016. α-Mangostin from Garcinia mangostana Linn: an updated review of its pharmacological properties. Arabian Journal of Chemistry, 45(02): 220-228. DOI: https://doi.org/10.1016/j.arabjc.2014.02.011
Jivad, N., Bahmani, M. & Asadi-Samani, M. 2016. A review of the most important medicinal plants effective on wound healing on ethnobotany evidence of Iran. Scholar Research Library, 8(2): 353-357.
Kapp, S. & Santamaria, N. 2017. The financial and quality of life cost to patients living with a chronic wound in the community. International Wound Journal, 14(6): 1108-1119. DOI: https://doi.org/10.1111/iwj.12767
Lazarus, G.S., Cooper, D.M., Knighton, D.R., Margolis, D.J., Percoraro, R.E., Rodeheaver, G. & Robson, M.C. 1994. Definitions and guidelines for assessment of wounds and evaluation of healing. JAMA Dermatology, 2(3): 165-170. DOI: https://doi.org/10.1046/j.1524-475X.1994.20305.x
Lindley, L.E., Stojadinovic, O., Pastar, I. & TomicCanic, M. 2016. Biology and biomarkers for wound healing. Plastic and Reconstructive Surgery, 138(3): 18. DOI: https://doi.org/10.1097/PRS.0000000000002682
Liu, W.L., Jiang, Y.L., Wang, Y.Q., Li, Y.X. & Liu, Y.X. 2017. Combined debridement in chronic wounds: A literature review. Chinise Nursing DOI: https://doi.org/10.1016/j.cnre.2017.03.003
Research, 4(1): 5-8.
Lo, Z.J., Lim, X., End, D., Car, J., Hong, Q., Yon, E., Zhang, L., Chandrasekar, S., Tan, G.W.L., Chan, Y.M., Sim, S.C., Oei, C.W., Zhang, X., Dharmawan, A., Ng, Y.Z., Harding, K., Upton, Z., Yap, C.W. & Heng, B.H. 2020. Clinical and economic burden of wound care in the tropics: A 5-year institutional population health review. International Wound Journal, 17(3): p. 790-803. DOI: https://doi.org/10.1111/iwj.13333
Mohan, S., Syam, S., Abdelwahab, S.I. & Thangavel, N. 2018. An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: An in silico, in vitro and in vivo approach. Food and Function, 9(7): 3860-3871. DOI: https://doi.org/10.1039/C8FO00439K
Mustoe, T. 2004. Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy. The American Journal of Surgery, 187(5): S65-S70. DOI: https://doi.org/10.1016/S0002-9610(03)00306-4
Naji, S., Zarei, L., Pourjabali, M. & Mohammadi, R. 2017. The extract of Lycium depressum stocks enhances wound healing in streptozotocin induced diabetic rats. The International Journal of Lower Extremity Wounds, 16(2): 85-93. DOI: https://doi.org/10.1177/1534734617700538
Nussbaum, C., Bannenberg, S., Keul, P., Graler, M.H., Goncalves-de-Albuquerque, C.F., Korhonen, H., Wnuck-Lipinski, K., Heusch, G., Neto, H. & Rohwedder, I. 2015. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications, 6(1): 1-12. DOI: https://doi.org/10.1038/ncomms7416
Obolskiy, D., Pischel, I., Siriwatanametanon, N. & Heinrich, M. 2009. Garcinia mangostana L.: A phytochemical and pharmacological review. Phytotherapy Research, 23(8): 1047-1065. DOI: https://doi.org/10.1002/ptr.2730
Ovalle-Magallanes, B., Eugenio-Pérez, D. & Pedraza-Chaverri, J. 2017. Medicinal properties of mangosteen (Garcinia mangostana L.): A comprehensive update. Food and Chemical Toxilogy, 109: 102-122. DOI: https://doi.org/10.1016/j.fct.2017.08.021
Panawes, S., Ekabutr, P., Niamlang, P., Pavasant, P. & Chuysinuan, P. 2017. Antimicrobial mangosteen extract infused alginate-coated gauze wound dressing. Journal of Drug Delivery Science and Technology, 41: 182-190. DOI: https://doi.org/10.1016/j.jddst.2017.06.021
Patel, S., Maheshwari, A. & Chandra, A. 2016. Biomarkers for wound healing and their evaluation. Journal of Wound Care, 25(10): 46-55. DOI: https://doi.org/10.12968/jowc.2016.25.1.46
Pedraza-Chaverri, J., Cardenas-Rodriguez, N., Orozco-Ibarra, M. & Perez-Rojas, J.M. 2008. Medicinal properties of mangosteen (Garcinia mangostana). Food and Chemical Toxicology, 46(10): 3227-3239. DOI: https://doi.org/10.1016/j.fct.2008.07.024
Peppa, M., Stavroulakis, P. & Raptis, S.A. 2009. Advanced glycoxidation products and impaired diabetic wound healing. The International Journal of Tissue Repair and Regeneration, 17(4): 461-472. DOI: https://doi.org/10.1111/j.1524-475X.2009.00518.x
Phillips, T.J. & Dover, J.S. 1991. Leg ulcers. Journal of the American Academy of Dermatology, 725(6): 965-987. DOI: https://doi.org/10.1016/0190-9622(91)70295-D
Rizqiawan, A., Aprilia, O., Pakpahan, R.G.,Rodherika, E. & Setyowati, A. 2021. Application of mangosteen peel extract (Garcinia mangostana Linn.) to TGF-1, PDGF-B, FGF-2 and VEGF-A expression on human gingival fibroblast cell culture (In Vitro Study). Journal of International Dental and Medical Research, 14(1): 119-124.
Schultz, G. S., Davidson, J. M., Kirsner, R. S., Bornstein, P. & Herman, I.M. 2011. Dynamic reciprocity in the wound microenvironment. Wound Repair and Regeneration, 19(2): 134-148. DOI: https://doi.org/10.1111/j.1524-475X.2011.00673.x
Sen, C. K., Gordillo, G.M., Roy, S., Kirsner, R., Lambert, L., Hunt, T.K., Gottrup, F., Gurtner, G.C. & Longaker, M.T. 2009. Human skin wounds: A major and snowballing threat to public health and the economy. Wound Repair and Regeneration, 17(6): 763-771. DOI: https://doi.org/10.1111/j.1524-475X.2009.00543.x
Shafy, G.M., Jassim, A.M.N. & Mohammed, M.T. 2019. Study of phytochemical, antioxidant and anti-inflammatory of mangosteen (G. Mangostana) and its ability to wound healing. Plant Archives, 19(1): 665-673.
Shandiz, H.T., Razavi, B.M. & Hosseinzadeh, H. 2017. Review of Garcinia mangostana and its xanthones in metabolic syndrome and related complications. Phytotherapy Research, 31(8):1173-1182. DOI: https://doi.org/10.1002/ptr.5862
Siriwattanasatorn, M., Itharat, A., Thongdeeying, P. & Ooraikul, B.A. 2020. In vitro wound healing activities of three most commonly used thai medicinal plants and their three markers. Complementary and Alternative Medicine, 6: 1-11. DOI: https://doi.org/10.1155/2020/6795383
Slavich, G.M. & Irwin, M.R. 2014. From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychologial Bulletin, 140(3): 774. DOI: https://doi.org/10.1037/a0035302
Sombolayuk, H.B., Djawad, K., Wahab, S., Miskad, U.A. & Alam, G. 2019. The effectivity of topical mangosteen pericarp extract cream on wound healing in Swiss albino mice. Journal of Biological Research, 92(2): 8250. DOI: https://doi.org/10.4081/jbr.2019.8150
Sunarjo, L., Suharti, O., Susanto, H. S. & Fatmasari, D. 2020. Impact of mangosteen rind on TNF-α Level of diabetic wound healing. NeuroQuantology, 18(2): 173-179. DOI: https://doi.org/10.14704/nq.2020.18.2.NQ20142
Suttirak, W. & Manurakchinakorn, S. 2014. In vitro antioxidant properties of mangosteen peel extract. Journal of Food Science and Technology, 51(12): 3546-3558. DOI: https://doi.org/10.1007/s13197-012-0887-5
Tantra, I., Rizqiawan, A. & Sumarta, N.P.M. 2021. Alpha-mangostin as potent osteogenesis and anti-inflammation bioactive material: Literature Review. Natural Volatiles & Essential Oils, 8(6): 4875-4884.
Tatiya-Aphiradee, N., Chatuphonprasert, W. & Jarukamjorn, K. 2019. Anti-inflammatory effect of Garcinia mangostana Linn. pericarp extract in methicillin-resistant Staphylococcus aureusinduced superficial skin infection in mice. Biomedicine and Pharmacotherapy,111: 705-713. DOI: https://doi.org/10.1016/j.biopha.2018.12.142
Thakur, R., Jain, N., Pathak, R. & Sandhu, S.S. 2011. Practices in wound healing studies of plants. Complementary Alternative Medicine, 2011: 438056. DOI: https://doi.org/10.1155/2011/438056
Thangapazham, R.L., Sharad, S. & Maheshwari, R.K. 2016. Phytochemicals in wound healing. Advances in Wound Care, 5(5): 230-241. DOI: https://doi.org/10.1089/wound.2013.0505
Wathoni, N., Sari, D.P., Suharyani, I., Motoyama, K., Mohammed, A.F.A., Cahyanto, A., Abdassah, M. & Muchtaridi, M. 2020. Enhancement of α-Mangostin wound healing ability by complexation with 2-hydroxypropyl- β-cyclodextrin in hydrogel formulation. Pharmaceuticals, 13(10): 290. DOI: https://doi.org/10.3390/ph13100290
Wulandari, P.A.C., Ilmi, Z.N., Husen, S.A., Winarni, D., Alamsjah, M.A., Awang, K., Vastano, M., Pellis, A., MacQuarrie, D. & Pudjiastuti, P. 2021. Wound healing and antioxidant evaluations of alginate from Sargassum ilicifolium and mangosteen rind combination extracts on diabetic mice model. Applied Sciences, 11(10): 4651. DOI: https://doi.org/10.3390/app11104651
Yang, R., Li, P., Zhang, Q., Bai, X., Wang, L., Xiao, Y., Sun, L., Yang, Q. & Yan, J. 2017. Xanthones from the pericarp of Garcinia mangostana. Journal of Synthetic Chemistry and Nature Product Chemistry, 22(5): 683. DOI: https://doi.org/10.3390/molecules22050683
Yao, Z., Niu, J. & Cheng, B. 2020. Prevalence of chronic skin wounds and their risk factors in an inpatient hospital setting in northern China. Advance Skin Wound Care, 33(9): 1-10. DOI: https://doi.org/10.1097/01.ASW.0000694164.34068.82
Yiemwattana, I. & Kaomongkolgit, R. 2015. Alphamangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts. Odontology, 103(3): 348-355. DOI: https://doi.org/10.1007/s10266-014-0160-7
Yussof, S. J. M., Omar, E., Pai, D. R. & Sood, S. 2012. Cellular events and biomarkers of wound healing. Indian Journal of Plastic Surgery, 45(02): 220-228. DOI: https://doi.org/10.4103/0970-0358.101282
Zhang, K.J., Gu, Q.I., Yang, K., Ming, X. & Wang, J.X. 2017. Anticarcinogenic effects of α-mangostin: A review. Planta Medica, 83(3): 188-202. DOI: https://doi.org/10.1055/s-0042-119651
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