• TING WEI NG Division of Biomedical Science, Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Selangor, Malaysia
  • PAULINA PEI SUU TAN Division of Biomedical Science, Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Selangor, Malaysia
  • HOOI MIN LIM Department of Primary Care Medicine, Faculty of Medicine, University Malaya 50603 Kuala Lumpur, Malaysia
  • DEVARAJ NAVIN KUMAR Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  • SHAMSUL MOHD ZAIN Department of Pharmacology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia https://orcid.org/0000-0002-3441-6659
  • TECK YEW LOW UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia https://orcid.org/0000-0001-7878-7534
  • YUH FEN PUNG Division of Biomedical Science, The University of Nottingham Malaysia https://orcid.org/0000-0001-6195-3970


hypercholesterolemia, hyperlipidaemia, hypertension, diabetes, atheroslerosis, hyperlipidemia


Cardiovascular disease (CVD) and its associated risk factors have been ranked the number 1 cause of mortality in non-communicable diseases worldwide and Malaysia. The high statistic in CVD mortality indicates gaps and limitations in current treatment strategies using long-term drug prescription therapies. Hence, an immediate quest for alternative and effective treatments is needed. Medicinal herbs, which are ethnopharmacologically used to treat a wide range of conditions, have been used as an alternative or supplementary treatment for CVDs and their associated risk factors. The roots of Salviae miltiorrhizae have been traditionally used for centuries to treat various diseases including neurological disorders, cancer, and even coronary heart disease. Increasing evidence demonstrated a pharmacological basis for the action of S. miltiorrhizae and its active compounds, suggesting its potential in treating CVD. The objectives of this review were first to summarize published literature and synthesize the new body of knowledge on the use of S. miltiorrhizae as the potential medicinal herb that will positively impact the cardiovascular system, and secondly to elucidate the underlying mechanisms involved in promoting cardiovascular health. It is hoped that identification of key regulatory pathways by lipophilic and hydrophilic active compounds from S. miltiorrhizae will aid further investigation of its safety and efficacy to promote the use of evidence-based traditional medicinal herbs in alleviating symptoms and improve the prognosis of CVDs and their associated risk factors.


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How to Cite

NG, T. W., TAN, P. P. S., LIM, H. M., KUMAR, D. N., MOHD ZAIN, S., LOW, T. Y. ., & PUNG, Y. F. (2022). POTENTIAL MEDICINAL HERB FOR CARDIOVASCULAR HEALTH: A COMPREHENSIVE REVIEW ON Salviae miltiorrhizae . Malaysian Applied Biology, 51(1), 1–20. https://doi.org/10.55230/mabjournal.v51i1.2056



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